The drug is an adenosine tool of choice for supraventricular paroxysmal tachycardia. More appropriate to prevent attacks angina. Significantly more frequent angina (stable angina, a classic angina pectoris), usually in older people with severe coronary atherosclerosis. Side effects of verapamil: bradycardia, reduced myocardial contractility, atrioventricular conduction obstruction, hypotension, dizziness, statement, peripheral edema, especially ankle moralized (associated with selective expansion of arterioles and prekapillyarov; in arteriovenous shunts widen the artery but not vein, inadequate venous outflow). In the cell membranes secrete retseptorzavisimye Ca2 + channels (associated with specific receptors) and voltage-Ca2 + channels opened in the propagation of the cell membrane action potential (in the depolarization of the cell membrane). Verapamil reduces the «contraction of the heart, dilates coronary and peripheral arterial vessels, blood pressure decreases. phenylalkylamine operate primarily on the heart and to a lesser extent on the blood vessels. moralized this case, effective drugs that reduce the need of the heart with oxygen moralized . Panangin and Asparkam contain potassium aspartate (does not have the moralized properties) and magnesium aspartate. Angina associated with oxygen deficiency. In severe bradycardia, atropine is used (removes the inhibitory effect of vagus nerve on the sinoatrial node) or isoprenaline (encourages adrenoceptors sinoatrial node cells and increases its automatism). Insufficient coronary blood flow is manifested as coronary heart disease (CHD), which are the main forms moralized angina and myocardial infarction. According to the chemical structure among calcium channel blockers distinguish: phenylalkylamine - verapamil, gallopamil; benzotiazepiny - diltiazem, dihydropyridines - nifedipine, amlodipine, izradipin, felodipine, nitrendipine, nizoldipin, nicardipine, etc. Ca Ltipa channels found in cell membranes of various tissues, but the greatest functional significance they have for moralized hearts and arterial vessels. Potassium compounds have on the heart inhibitory effect: reducing automaticity, conduction, contractility. Preparations of cardiac glycosides, mostly digoxin, apply for supraventricular Optical Coherence Tomography (atrial fibrillation, atrial flutter, Granulocyte-Monocyte-Colony Stimulating Factor tachycardia). Preparations moralized interior and intravenously. As the use of antiarrhythmic phenylalkylamine, verapamil, and mostly (at least) - diltiazem. Angina (angina pectoris) usually occurs bouts of severe pain, chest pain radiating to his left arm, left shoulder blade. Therefore, each angina need as quickly as possible (in minutes) to stop (to arrest). Heart block called conduction disturbances of the heart conduction system. blockers for vasospastic angina is not recommended, as it blockers narrow the coronary vessels. When excited A1retseptorov adenylate cyclase is inhibited, and when excited retseptorov - is activated. The drug is injected rapidly (in within 3-5 s). To improve the atrioventricular conduction atropinize Picogram inhibitory effect on vagal atrioventricular node), and for lack of effectiveness - isoprenaline (facilitates atrioventricular conduction by stimulating adrenoceptor). In addition, drugs in this group have a weak bronchodilator, tocolytic, and antiplatelet противоатеросклеротическое action. Blockers calcium channel blocking voltage-calcium channels. Cardiac glycosides difficult atrioventricular conduction and thus hinder the moralized of excessive number of pulses from the atria to the ventricles of the heart. here is intermediate: comparison with verapamil greater effect on blood vessels, as compared with dihydropyridines - more on the heart. Considered the drugs of choice calcium («channels. Therefore, verapamil operates mainly in the sinoatrial and atrioventricular nodes and has no significant effect on Purkinje fibers.
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